Vaidyaratnam P. S. Varier, who completed his studies in Ayurveda in the traditional “Gurukula” system, established Arya Vaidya Samajam in 1902 and convened a conclave of major Ayurveda practitioners from all three provinces of present-day Kerala in 1903.

A branch of Arya Vaidya Sala started functioning at Kozhikode in 1916 and adjacent to it, Arya Vaidya Padasala was established in 1917. The dream of a visionary fructified on 14th January 1917.

During the tenure of Chief Minister Sri. C. Achutha Menon, the Kerala Ayurvedic Studies & Research Society was formed in 1975 and took over the College and its assets on 1st April 1976 to promote Ayurveda studies and research in collaboration with institutions in India and abroad.

A Publication Wing by name BHISHAK was instituted in 1993, and a Centre for Yoga by name CRIYA offering certificate courses was started in 1998.